Regulating Energy Homeostasis

Peripheral Pathways Regulating Energy Homeostasis

The incidences of both obesity and type 2 diabetes mellitus are rising at epidemic proportions and have emerged as a major threat to human health in the late twentieth and early twenty-first century. Growing evidence suggests that nutrient and hormonal signals converge and act directly on brain centers, leading to changes in fuel metabolism. Many newly discovered molecules that are proposed to play an active role in the physiology and pathophysiology of energy homeostasis have changed our understanding of obesity and metabolism and have attracted the attention of many researchers who strive to investigate and characterize the mechanisms underlying energy homeostasis. The purpose of this information is to summarize POH's current understanding of peripheral pathways regulating energy homeostasis and to outline new targets for the treatment of obesity, metabolic disorders, and associated co-morbidities.